Akademik Veri Yönetim Sistemi
Cytokine, cilt.23, sa.1-2, ss.47-51, 2003 (SCI-Expanded, Scopus)
We investigated the effects of pro-inflammatory cytokines of pericardial fluid on hemodynamic parameters in patients undergoing coronary artery surgery. Seventy-eight patients were included in the study and they were allocated to three groups: group 1, stable angina pectoris (SAP, n=15); group 2, unstable angina pectoris (USAP, n=34); group 3, post-myocardial infarction (PMI, n=29). Pericardial fluid and arterial blood samples were obtained from all patients and interleukin (IL)-1β, IL-2 receptor, IL-6, IL-8 and tumor necrosis factor-alpha (TNF-α) levels were measured. Pericardial IL-1β concentration (pg/mL) was significantly higher in the USAP group (26.6 ± 10.9) compared to the SAP (5.0 ± 0.1) and PMI (5.8 ± 1.0) groups. IL-2R, IL-6, IL-8 and TNF-α concentrations of pericardial fluid were significantly higher than serum in all groups; difference was more prominent in the PMI group compared to the SAP and the USAP groups. Serum IL-1β concentrations (pg/mL) were significantly higher in the USAP group (21.8 ± 3.4) compared to the SAP group (5.0 ± 0.1) and the PMI group (5.4 ± 1.6). Cardiac index (CI) before opening the pericardial sac was found to be lower in the USAP group (1.6 ± 0.3 L/min/m2) compared to the SAP (2.2 ± 0.5 L/min/m2) and the PMI (2.1 ± 0.5 L/min/m2) groups (p=0.028 and p=0.011, respectively). In the USAP group, there was a relationship between reduction of CI and increase of IL-1β levels in serum and pericardial fluid. © 2003 Elsevier Ltd. All rights reserved.