Comparison of the effects of rocuronium, mivacurium and cisatracurium on hemodynamic parameters, intubation conditions and neuro-muscle junction in paediatric patients Rokuronyum, mivakuryum ve cisatrakuryum'un cocuklarda sinir-kas kavsagina, entubasyon kosullarina ve hemodinamik parametreler uzerine etkilerinin karsilastirilmasi
Turk Anesteziyoloji ve Reanimasyon, cilt.28, sa.1, ss.29-32, 2000 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 1
- Basım Tarihi: 2000
- Dergi Adı: Turk Anesteziyoloji ve Reanimasyon
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.29-32
- Anahtar Kelimeler: Cisatracurium, Mivacurium, Neuromuscular blockage, Paediatric anaesthesia, Rocuronium
- Trakya Üniversitesi Adresli: Evet
Özet
In our study our aim was to evaluate the effects of non-depolarizing muscle relaxants rocuronium (R), mivacurium (M) and cisatracurium (C) on nerve-muscle function, intubation conditions and haemodynamic parameters in paediatric patients under sevoflurane anaesthesia. Our study is performed on 60 ASA I-II class patients ages ranging between 1-7 years planned for elective surgery patients were randomized into 3 groups (n=20) according to the muscle relaxants planned to be used. All patients received 0.015 mg/kg atropin and 0.06 mg/kg midazolam İM for premedication. HR, MAP and SpO2 values were recorded before muscle relaxant administration as baseline, immediately after muscle relaxant administration, immediately after intubation, 5 and 10 minutes after intubation. In all groups anaesthesia induction was provided with 50% O2 + 50% N2O with 5% sevoflurane following induction patients received either of R 0.6 mg/kg, M 0.2 mg/kg or C 0.1 mg/kg. At equal times T 95, T 25, T 25-75 and T 70 parameters were recorded by TOF-Guard monitore. Endotracheal intubation quality was evaluated with Clarke and Mirakhur evaluation scale. In comparison of intubation scores no significant statistical difference was found between R, M and C groups. In comparison of muscle relaxation T 95 values were recorded shorter in R group than in M and C groups. T 25 values was found to be significantly shorter in M group when compared to the other groups. T 25-75 value was also noticed to be significantly short in M group. In comparison of T 70 value between groups it was found to be significantly shorter in M group than R and C group. This value was found longer in C group. As a result we have concluded that rocuronium having short duration of onset is the agent to be preferred in induction and emergency states, short clinical effects and recovery time mivacurium the agent to be preferred in short durational operations. Since clinical effect time is long cisatracurium can be preferred in long durational operations.