The role of CD36 expression on survival and febrile neutropenia in patients with acute myeloid leukemia
Biomarkers, cilt.31, sa.4, ss.266-270, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 31 Sayı: 4
- Basım Tarihi: 2026
- Doi Numarası: 10.1080/1354750x.2026.2672956
- Dergi Adı: Biomarkers
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE
- Sayfa Sayıları: ss.266-270
- Anahtar Kelimeler: Acute myeloid leukemia, CD36, chemoresistance, febrile neutropenia, overall survival
- Trakya Üniversitesi Adresli: Evet
Özet
Background: Acute myeloid leukemia (AML) is a clonal malignancy characterized by impaired hematopoietic differentiation. CD36 is a transmembrane glycoprotein receptor for phospholipids, lipoproteins, and long-chain fatty acids, and has been implicated in chemoresistance. In this AML cohort we evaluated CD36 expression and its association with febrile neutropenia (FEN) and overall survival (OS) as a potential biomarker of infectious risk. Purpose: To assess whether CD36 expression may be associated with FEN and OS in AML. Methods: We conducted a retrospective single-center cohort study of patients with AML, evaluating flow cytometric CD36 expression and its associations with FEN and OS during follow-up. Results: Among 41 AML patients (median age, 61 years; 46.3% male), CD36 expression was <20% in 20 (48.8%) and ≥20% in 21 (51.2%). FEN occurred in 34 patients (82.9%), including 20/21 (95.2%) in the CD36 ≥ 20% group (p = 0.032). Patients with CD36 expression ≥20% also exhibited shorter OS and a higher hazard of death on univariable Cox regression (HR 3.161, 95% CI 1.276–7.827; p = 0.013). Conclusion: Higher CD36 expression in AML may be associated with more frequent FEN and reduced OS, suggesting its potential clinical relevance as a biomarker of infection-related vulnerability and adverse prognosis.