Prevention of radiation-induced liver and kidney toxicity: A role for amifostine Radyasyona baǧli oluşan karaciǧer ve böbrek toksitesini önlemede amifostinin rolü

KALDIR M. U., ÇALOĞLU V., ALAS R., Cermik T. F., ALTANER Ş., ESKİOCAK S., ...Daha Fazla

Turk Onkoloji Dergisi, cilt.22, sa.3, ss.105-117, 2007 (Scopus, TRDizin) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 3
  • Basım Tarihi: 2007
  • Dergi Adı: Turk Onkoloji Dergisi
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.105-117
  • Anahtar Kelimeler: Amifostine, Kidney/radiation effects, Liver/radiation effects, Radiotherapy/yan etki, Risk factors, Toxicity
  • Trakya Üniversitesi Adresli: Evet

Özet

Objectives: To investigate the protective effect of amifostine against radiation induced liver and kidney injury of rats, using scintigraphic and histopathologic parameters. Methods: Female Wistar Albino rats were randomly allocated to 3 groups: control, radiotherapy alone (RT), and amifostine+RT (n=10). Single-dose of 600 cGy X-ray was performed with a single field compromised liver and right kidney. Amifostine was administered intraperitoneally at a dose of 400 mg/kg, 30 minutes before irradiation. Scintigraphic evaluation was performed before irradiation and the end of the study at 6 nd month. Histopathologic examinations were performed post mortem. Results: A clear protective effect of amifostine against radiation-induced late damage in liver and kidney was found with scintigraphic evaluation. In addition, amifostine reduced the decrease of histopathologic changes for both of the tissues. Conclusion: The results showed that amifostine significantly reduced radiation-induced liver and kidney toxicity and therefore warrant additional study in a clinically relevant fractionated model.