Akademik Veri Yönetim Sistemi
Türk Onkoloji Dergisi, cilt.40, sa.1, ss.68-75, 2024 (ESCI, Scopus, TRDizin)
OBJECTIVE Modern radiotherapy (RT) techniques aim to preserve normal tissues as much as possible, though some nor- mal tissue may inevitably be included in the target volume. The study aimed to evaluate the potential protec- tive role of amifostine and L-carnitine against radiation-induced bladder toxicity and compare their effects. METHODS Experiments were conducted on 30 male Wistar Albino rats, divided into four groups: Control, AMI + RT, LC + RT, and RT alone. All groups received a 20 Gy dose of radiation, and histopathological evalu- ations were performed. RESULTS Statistically significant differences were found in epithelial desquamation, stromal edema, and vessel wall thickness in irradiated rats. Amifostine significantly decreased epithelial desquamation and vessel wall thickness changes but had no effect on stromal edema. L-carnitine had no statistically significant protective effect on epithelial desquamation, vessel wall thickness, and stromal edema. CONCLUSION This study is the first to demonstrate amifostine’s protective effect against radiation-induced bladder toxicity in a preclinical setting and to compare it with L-carnitine. Findings suggest that amifostine is more effective than L-carnitine in protecting against radiation-induced bladder damage.