Synthesis, spectral analysis, stability constants, antioxidant and biological activities of Co (II), Ni (II) and Cu (II) mixed ligand complexes of nicotinamide, theophylline and thiocyanate

ALTUN Ö., Şuözer M.

Journal of Molecular Structure, cilt.1149, ss.307-314, 2017 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1149
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.molstruc.2017.07.069
  • Dergi Adı: Journal of Molecular Structure
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.307-314
  • Anahtar Kelimeler: Antioxidant activity, Biological activity, Nicotinamide, Spectrophotometry, Stability constant, Theophylline
  • Trakya Üniversitesi Adresli: Evet

Özet

In the present study, transition metal complexes or coordination entities with metal precursors such as Co (II), Ni (II) and Cu (II) of mixed ligands namely, nicotinamide (NA), theophylline (TP) and KSCN in water were synthesized under refluxing conditions. The optimization of the reactions to obtain the composition of complexes was performed. The structural elucidation of the complexes was undertaken by using physico-chemical and spectroscopic methods (UV/Vis, FT-IR, Mass and XRD) and thermal analysis. The spectral measurements of mixed ligands with the Co (II), Ni (II) and Cu (II) complexes are compared with each other in determining which atoms of the ligand are coordinated to the metal ion. Based on spectral and magnetic moment measurements, all the coordination entities were identified as in distorted octahedral structure and have the form [M(NA)2 (TP)2(SCN)2]·xH2O. In addition, K (stability constant) and ΔG (Gibbs free energy) values were calculated by using the Babko and Stanley & Turner's methods. Antioxidant, antibacterial and antifungal activities of the complexes were studied.