Akademik Veri Yönetim Sistemi
Journal of Otolaryngology - Head and Neck Surgery, cilt.37, sa.6, ss.799-806, 2008 (SCI-Expanded, Scopus)
Purpose: To evaluate the prognostic factors affecting locoregional control (LRC) and overall survival (OS) of patients with laryngeal carcinoma who were not candidates for surgical treatment due to tumour or host factors but were treated with definitive radiotherapy (RT). atients and Methods: Sixty-three consecutive patients, treated with definitive RT between 1999 and 2005, were retrospectively analyzed. All patients had histologically proven squamous cell carcinomas of the larynx. The median age was 62 years (range 43-83 years). Follow-up ranged from 22 days to 68 months (median 32 months). Results: The LRC rates at 2 and 5 years were 70% and 48%. The 2-and 5-year OS rates were 65% and 40%. No statistically significant relationship was found between World Health Organization performance status score (WHO PS) and age (p =.21), tumour site (p =.42), overall stage (p =.11), T stage (p =.19), and N stage (p =.69). Multivariate analyses showed that a WHO PS score ≥ 2 (p <.0001) and RT treatment time ≥ 50 days (p =.0172) significantly decreased LRC. Moreover, a WHO PS score ≥ 2(p <.0001), RT treatment time ≥ 50 days (p =.0138), and RT dose < 66 Gy (p =.04) were significantly negative prognostic factors on OS. Conclusion: Definitive RT, in patients with early-and more advanced-stage squamous cell carcinoma of the larynx, is an important treatment option. It is clear that patients with good pretreatment PS would get better results from definitive RT. © 2008 The Canadian Society of Otolaryngology-Head & Neck Surgery.