Cerebral vasomotor reactivity in fibromyalgia patients and its relationship to central neuropathic pain
Ideggyogyaszati Szemle, cilt.69, sa.9-10, ss.341-348, 2016 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 69 Sayı: 9-10
- Basım Tarihi: 2016
- Doi Numarası: 10.18071/isz.69.0341
- Dergi Adı: Ideggyogyaszati Szemle
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.341-348
- Anahtar Kelimeler: Breath hold index, Central sensitization, Fibromyalgia, Neuropathic pain, Vasomotor reactivity
- Trakya Üniversitesi Adresli: Evet
Özet
Background - Cerebral vasomotor reactivity, defined as the cerebral vasculature response to hypoxia, is not well- understood in fibromyalgia (FM) patients. This study investigated the difference in the cerebrovascular reactivity (i.e., responsiveness to hypercapnia was evaluated by use of breath-holding index) to the breath-holding index (BHIAverage) between patients with fibromyalgia and a group of normal controls. Methods - The study included 40 FM patients and 40 healthy subjects. Cerebrovascular reactivity was evaluated using the BHIAverage, which is a nonaggressive, well-Tolerdted, real-Time, reproducible screening method to study cerebral haemodynamics. Insonation depth and basal velocity were symmetrical and not significantly different between the two groups (p>0.05). All patients completed the Revised Fibromyalgia Impact Questionnaire (FIQR), Hospital Anxiety and Depression Scale (HADS), visual analogue scale (VAS), and the somatization subscale of the SCL-90-R symptom checklist. Results - The BHIAverage ranged from 0.30 to 2.20 (mean 1.11 ±0.45) in the FM patients and 1.10 to 2.80 (mean 1.90±0.35) in the control group (pcO.OOl). Disease duration and right BHIAverage and left BH values exhibited a Conclusions - BHIAverage values showed that cerebrovascular reactivity in FM patients decreased in comparison to healthy individuals. BHIAverage decreased as disease duration and severity increased. Cerebrovascular reactivity decreased in FM patients, and this phenomenon should be accepted as an abnormality. Additionally, this outcome may have been the result of a mechanism responsible for central neuropathic pain.