Epidural administration of clonidine+bupivacaine and tramadol+bupivacaine combinations during vertebral surgery and assessment of its effect on postoperative analgesia and hemodynamics Vertebra cerrahisinde epidural klonidin+bupivakain ve tramadol+bupivakain kombinasyonunun postoperatif analjezi ve hemodinami uzerine etkisi
Turk Anesteziyoloji ve Reanimasyon, cilt.28, sa.2, ss.88-92, 2000 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 2
- Basım Tarihi: 2000
- Dergi Adı: Turk Anesteziyoloji ve Reanimasyon
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.88-92
- Anahtar Kelimeler: Bupivacaine, Clonidine, Epidural catheter, Postoperative analgesia, Tramadol, Vertebral surgery
- Trakya Üniversitesi Adresli: Evet
Özet
This study was applied on 30 cases to assess the effect of combinations of clonidine+bupivacaine and tramadol+bupivacaine on vital signs. Patients were allocated randomly to one of two groups. Group 1 (n=15) received doses of 1 μg/kg clonidine+4 mL 0.5 % bupivacaine and Group II (n=15) doses of 75 mg tramadol+4 mL 0.5 % bupivacaine. Mean arterial pressure, heart rate, SpO2, respiratory rate, pain and sedation scores, analgesia onset and side effects were recorded for 24 hours. Statistically there was no difference in mean arterial pressure, heart rate, SpO2, respiratory rate, and sedation scores between Group I and II (p>0.05). Within 1/2. hours, postoperatively there was no difference in VAS between Group I and II (p>0.05). While within the 2,4,6 hours postoperatively there was significant decrease in VAS of Group I (p<0.05). Postoperatively within 12 and 24 hours there were no significant differences detected between two groups (p>0.05). Postoperative onset of analgesia was 6.11±3.19 hours in group I, 4.50±2.09 hours in group II. The difference between two groups was significant (p<0.05). Significant increase in side effects founded in group II was more than group I (p<0.05). We conclude that epidural administrations of clonidine+bupivacaine combination is safe and provide effective analgesia, produces no hemodynamic disturbances, and has no effect on respiratory parameters.