Glucose-induced alteration of accumulation of organotechnetium complexes accumulation in Pgp-negative tumor-bearing mice
Cancer Biotherapy and Radiopharmaceuticals, cilt.24, sa.3, ss.333-338, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 24 Sayı: 3
- Basım Tarihi: 2009
- Doi Numarası: 10.1089/cbr.2008.0546
- Dergi Adı: Cancer Biotherapy and Radiopharmaceuticals
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.333-338
- Anahtar Kelimeler: EATC, Glucose, MIBI, Tetrofosmin
- Trakya Üniversitesi Adresli: Evet
Özet
The biologic and microenvironmental factors determining 99mTc sestamibi (MIBI) and 99mTc tetrofosmin (TF) uptake in breast tumors are incompletely understood, especially in P-glycoprotein (Pgp)-negative tumors. We analyzed the influence of glucose administration on the uptake and retention of MIBI and TF in Pgp-negative tumor-bearing mice in vivo. Twenty (20) mice bearing Ehrlich ascites tumor cell (EATC) xenografts were divided into four groups: (1) MIBI, (2) MIBI+glucose, (3) TF, and (4) TF+glucose. Glucose was administered (5.0g/kg body weight) intraperitoreally (i.p.) 1 hour before scintigraphy. There were significant differences between the E-UPR MIBI and MIBI+glucose groups (p=0.009) and minor differences in L-UPR between these groups (p=0.04). There was a significant inverse correlation between E-UPR of MIBI and glucose levels (r=0.71, p=0.02). Comparing the four groups, the highest E-UPR was obtained in the MIBI group (p=0.006). Other parameters were not different in the MIBI and MIBI+glucose groups and in the TF and TF+glucose groups. Increased blood glucose level affected the MIBI uptake of tumor tissue, particularly for E-UPR. We suggest that these findings were due to basically decreased blood flow and secondarily decreased extracellular pH. However, glucose administration did not affect TF. © 2009, Mary Ann Liebert, Inc. 2009.