Akademik Veri Yönetim Sistemi
International Journal of Radiation Oncology Biology Physics, cilt.60, sa.2, ss.564-569, 2004 (SCI-Expanded, Scopus)
The purpose of this study was to determine by using 99mTc- diethylenetriaminepentaacetic acid (DTPA) lung scintigraphy whether amifostine given before irradiation protects alveolocapillary integrity in a rabbit model. Twenty white New Zealand rabbits were randomly divided into 4 groups: (1) control (CONT), (2) amifostine alone (AMF), (3) radiation (RAD), and (4) radiation plus amifostine (RAD+AMF). The AMF and RAD+AMF groups received amifostine. The RAD and RAD+AMF groups were irradiated to the right hemithorax with a single dose of 20 Gy using a 60Co treatment unit. Amifostine (200 mg/kg) was given i.p. 30 min before irradiation. The 99mTc-DTPA radioaerosol study was performed 14 day after irradiation. The mean clearance rate of 99mTc-DTPA in control subjects was 140 ± 21 min. The highest t 1/2 value was noted in the RAD group (603 ± 105 min, p = 0.001). There were no significant differences between the 99mTc-DTPA lung clearance rates of the CONT, RAD+AMF (238 ± 24 min), and AMF groups (227 ± 54 min). The mean penetration index values of CONT, RAD, AMF, and RAD+AMF are 63% ± 1.6%, 63% ± 2.5%, 60% ± 2.9%, and 63% ± 2%, respectively. We concluded that amifostine treatment before the lung irradiation protects the lung alveolocapillary integrity. This study confirms the protective effect of amifostine in an acute phase of radiation lung injury. © 2004 Elsevier Inc.