Effectiveness of topical intranasal curcumin in the experimentally induced allergic rhinitis model in rats (revised)

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Demir E., Koten M., Keskin F. E. U., ERYILDIZ C., GÜVEN S. G.

Allergologia et Immunopathologia, cilt.54, sa.2, ss.135-142, 2026 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 2
  • Basım Tarihi: 2026
  • Doi Numarası: 10.15586/aei.v54i2.1719
  • Dergi Adı: Allergologia et Immunopathologia
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, DIALNET
  • Sayfa Sayıları: ss.135-142
  • Anahtar Kelimeler: allergic rhinitis, anti-inflammatory effects, histopathological improvement, IgE Modulation, intranasal curcumin
  • Trakya Üniversitesi Adresli: Evet

Özet

Curcumin, a flavonoid derived from turmeric, has demonstrated antioxidant, anti-inflammatory, and antiallergic effects. This study evaluated the therapeutic efficacy of intranasal curcumin in an allergic rhinitis (AR) rat model. Forty rats were randomized into four groups: a sham control, an AR model with no treatment (negative control), an AR model treated with intranasal mometasone furoate (positive control), and an AR model treated with intranasal curcumin. Allergic symptoms (sneezing, itching, nasal discharge) were evaluated by both unblinded and blinded observers. Serum Ovalbumin (OVA)-specific IgE levels were measured using ELISA. Nasal mucosal histopathology (edema, cilia loss, goblet cell hyperplasia, inflammation, eosinophilia) was assessed by light microscopy. Intranasal curcumin significantly improved histopathological findings and reduced allergic symptoms, with efficacy comparable to steroid treatment. It alleviates AR symptoms and inflammation, suggesting a promising, low-cost alternative for AR management.