Synthesis and in vitro biological activity of new 4,6-disubstituted 3(2H)-pyridazinone-acetohydrazide derivatives

Sukuroglu M., Onkol T., KAYNAK ONURDAĞ F., Akalin G., Fethi Şahin M.

Zeitschrift fur Naturforschung - Section C Journal of Biosciences, cilt.67 C, sa.5-6, ss.257-265, 2012 (SCI-Expanded, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 67 C Sayı: 5-6
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1515/znc-2012-5-604
  • Dergi Adı: Zeitschrift fur Naturforschung - Section C Journal of Biosciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.257-265
  • Anahtar Kelimeler: Antimicrobial Activity, Benzyliden-acetohydrazide, Pyridazinone
  • Trakya Üniversitesi Adresli: Hayır

Özet

New 3(2H)-pyridazinone derivatives containing a N'-benzyliden-acetohydrazide moiety at position 2 were synthesized. The structures of these newly synthesized compounds were confirmed by IR, 1H NMR, and MS data. These compounds were tested for their antibacterial, antifungal, antimycobacterial, and cytotoxic activities. The compounds 2-[4-(4-chlorophenyl)- 6-(morpholin-4-yl)-3-oxo-(2H)-pyridazin-2-yl]-N'-(4-tert-butylbenzyliden)acetohydrazide and 2-[4-(4-chlorophenyl)-6-(morpholin-4-yl)-3-oxo-(2H)-pyridazin-2-yl]-N'-(4-chlorobenzyliden) acetohydrazide exhibited activity against both Gram-positive and Gram-negative bacteria. Most of the compounds were active against E. coli ATCC 35218. The preliminary results of this study revealed that some target compounds exhibited promising antimicrobial activities.