The results of hemoglobinopathy screening in hatay, the southern part of Turkey Türkiye’nin güneyinde hatay’da hemoglobinopati tarama sonuçları
Journal of Clinical and Analytical Medicine, cilt.7, sa.1, ss.6-9, 2016 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 7 Sayı: 1
- Basım Tarihi: 2016
- Doi Numarası: 10.4328/jcam.2427
- Dergi Adı: Journal of Clinical and Analytical Medicine
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.6-9
- Anahtar Kelimeler: Hemoglobinopathy screening, Sickle cell anemia, Β-thalassemia
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Trakya Üniversitesi Adresli: Evet
Özet
Aim: β-Thalassemia and hemoglobinopathies are common genetic disorders in Turkey. Because of this reason, either anemic people or couples before marriage are investigated for hemoglobinopathies routinly. In this retrospec-tive study, our aim was to determine the frequency of β-thalassemia and hemoglobinopathies in Hatay, which is located in the southern part of Turkey. Material and Method: In this study, data from 70226 individuals, admitted to Antakya State Hospital Hemoglobinopathy Center in Hatay, both for the rea-son of anemia and before marriage investigations, were evaluated between January 2006 and October 2012. The blood samples were collected into EDTA-containing tubes and hematological parameters were analyzed using a Sysmex XT-2000i Hematology Analyzer. High performance liquid chromatog-raphy technique was used to determine the type of hemoglobin. Results: The frequency of hemoglobinopaties were 6% β-Thalassemia trait, 6.3% sickle cell trait, 12.9% α-thalassaemia trait? and 4.2% other abnormal hemoglo-binopaties variants. We detected 49 cases with homozygot β-thalassaemia, 60 cases with homozygot haemoglobin S, 33 cases with HbH disease (thal-assaemia intermedia) among all. Discussion: The frequency of β-thalassemia trait and other haemoglobinopathies in Hatay is found to be quite high as compared with other provinces in Turkey.