Nephrolithiasis in ankylosing spondylitis and its relationship with disease assessment scales

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rezvani a., Aktas I., Tastekin N., ÇELİKER R., SARIKAYA S., DURSUN E., ...Daha Fazla

İstanbul Kuzey Klinikleri, cilt.6, sa.3, ss.254-259, 2019 (TRDizin)

Özet

OBJECTIVE: The aim of this study was to investigate the frequency of renal calculi in patients with ankylosing spondylitis(AS) and to determine its relationship with disease assessment variables.METHODS: The study was designed retrospectively, and it included a cohort of 320 patients with AS diagnosed using theModified New York Criteria. A total of 119 patients who underwent renal ultrasonography (USG), in who the erythrocyte sedimentation rate, C-reactive protein, blood calcium, phosphorus, Vitamin D, parathormone, and urinary calcium excretion weremeasured, and who also had lateral cervical and lumbar radiography in the same time period were extracted from the cohort. Allpatients’ demographic characteristics and the results of blood and urine tests were recorded. The Ankylosing Spondylitis DiseaseActivity Index (BASDAI), Ankylosing Spondylitis Functional Index (BASFI), Ankylosing Spondylitis Mobility Index (BASMI), andModified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) were evaluated in all patients.RESULTS: Thirteen of the 119 patients had renal calculi confirmed by USG data. The frequency of nephrolithiasis detectedby USG was 10.9% in patients with AS. The disease lasted significantly longer in patients with renal calculi ([nephrolithiasis(+): 18.39±8.72 years; nephrolithiasis (−): 12.02±8.43 years, p=0.01]). The BASMI total score was significantly higher inthe group of patients with renal calculi. There was not any significant difference in terms of blood samples, HLA-B27, BASDAI,BASFI, and mSASSS between groups.CONCLUSION: The frequency of renal stones is increased in patients with AS compared to healthy population. Especiallypatients who had AS for a long time and higher BASMI values are more susceptible to renal calculi. It is important to pointout that the results of this type of studies would be more reliable if the study is conducted on large patient groups and population-based prevalence