Tetrasomy 18p in a Twin Pregnancy with Diverse Expression in Both Fetuses

İNAN C., SAYIN N. C., Atlı E., Ulusal S., Erzincan S., Uzun I., ...Daha Fazla

Fetal and Pediatric Pathology, cilt.35, sa.5, ss.339-343, 2016 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 5
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1080/15513815.2016.1188870
  • Dergi Adı: Fetal and Pediatric Pathology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.339-343
  • Anahtar Kelimeler: monozygotic twins, prenatal diagnosis, tetrasomy 18p
  • Trakya Üniversitesi Adresli: Evet

Özet

Tetrasomy 18p, characterized by the presence of four copies of the short arm of chromosome 18, is considered to occur with the nondisjunction in meiosis II after the errors in the meiotic and early postmeiotic mitotic division in the centromere. It is accompanied by various abnormalities including congenital heart defects, lower extremity abnormalities, micrognathia, high arched palate, kyphoscoliosis, microcephaly, myelomeningocele, hernia and renal anomalies. We present the first case of a dichorionic diamniotic twin pregnancy in which both fetuses were affected by tetrasomy 18p, but with discordant morphology, detected in one twin in the first but in the other in the second trimester.