Synthesis of novel 2-[4-(4-substitutedbenzamido/phenylacetamido) phenyl]benzothiazoles as antimicrobial agents

Bolelli K., Yalcin I., Ertan-Bolelli T., Özgen S., KAYNAK ONURDAĞ F., YILDIZ İ., ...Daha Fazla

Medicinal Chemistry Research, cilt.21, sa.11, ss.3818-3825, 2012 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 11
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1007/s00044-011-9918-4
  • Dergi Adı: Medicinal Chemistry Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3818-3825
  • Anahtar Kelimeler: Antibacterial activity, Antifungal activity, Benzothiazole, Multi-drug resistance
  • Trakya Üniversitesi Adresli: Hayır

Özet

A new series of 2-[4-(4-substitutedbenzamido/ phenylacetamido)phenyl] benzothiazole derivatives (6a-k) were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli with their drug-resistant isolates and a yeast Candida albicans. Microbiological results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms at minimum inhibitory concentration (MIC) values between 100 and 6.25 lg/ml. Compounds 6d and 6k exhibited significant antibacterial activity showing 6.25 lg/ml MIC values against drugresistant S. aureus and P. aeruginosa isolates, respectively. © Springer Science+Business Media, LLC 2011.