Relationship between second-trimester amniotic fluid levels of Prokineticin-1 and Matrix Metalloproteinase-2 with adverse pregnancy outcome

Erzincan, Selen; Varol, Fusun; İNAN, CİHAN; SAYIN, NİYAZİ

doi:10.1016/j.placenta.2017.12.015

Relationship between second-trimester amniotic fluid levels of Prokineticin-1 and Matrix Metalloproteinase-2 with adverse pregnancy outcome

Erzincan S. G., Varol F. G., İNAN C., SAYIN N. C.

Placenta, cilt.62, ss.25-27, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 62
Basım Tarihi: 2018
Doi Numarası: 10.1016/j.placenta.2017.12.015
Dergi Adı: Placenta
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.25-27
Anahtar Kelimeler: Adverse pregnancy outcomes, Amniotic fluid, Metalloproteinase (MMP)-2, Placenta, Prokineticin 1
Trakya Üniversitesi Adresli: Evet

Özet

To investigate the levels of Prokineticin-1 (PROK1) and matrix metalloproteinase-2 (MMP-2) in second-trimester amniotic fluid (AF). AF samples were investigated in 81 patients. AF-PROK1 and AF-MMP-2 were not significantly associated with adverse pregnancy outcomes (preeclampsia, intrauterine growth retardation, spontaneous preterm birth, gestational diabetes, gestational hypertension). AF-PROK1 levels in patients with abnormal first-trimester screening were significantly higher than those who underwent amniocentesis due to abnormal second-trimester screening tests (p =.04). AF-PROK1 or AF-MMP-2 do not have a role in the prediction of adverse pregnancy outcomes.