Labor induction in term premature rupture of membranes: Comparison between oxytocin and dinoprostone followed 6 hours later by oxytocin
American Journal of Obstetrics and Gynecology, cilt.206, sa.1, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 206 Sayı: 1
- Basım Tarihi: 2012
- Doi Numarası: 10.1016/j.ajog.2011.07.035
- Dergi Adı: American Journal of Obstetrics and Gynecology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: dinoprostone, induction of labor, oxytocin, premature rupture of membranes
- Trakya Üniversitesi Adresli: Evet
Özet
The aim of this randomized study was to compare 2 protocols for inducing labor in women with premature rupture of membranes (PROM) at term. Women with PROM and a Bishop score ≤5 were randomly assigned to receive either an intravenous oxytocin infusion (n = 223) or a dinoprostone pessary followed 6 hours later by an intravenous oxytocin infusion (n = 227). Vaginal delivery within 24 hours of labor induction increased significantly with sustained-released dinoprostone followed by oxytocin infusion (78.5% vs 63.3%; relative risk, 1.23; 95% confidence interval, 1.091.39; P =.001). Maternal and neonatal outcomes were similar between the groups. Sustained-released dinoprostone followed 6 hours later by an oxytocin infusion in term women with PROM was associated with a higher rate of vaginal delivery within 24 hours, and no difference in maternal-neonatal complications was observed compared with oxytocin infusion alone.