The importance of pretreatment performance status and LDH level in patients with stage III-IV nasopharyngeal carcinoma Evre III-IV nazofarinks kanseri tanili hastalarda tedavi öncesi performans durumu ve LDH düzeyinin önemi

YÜRÜT ÇALOĞLU V., Çaloǧlu M., KARAGÖL H., Coşar-Alas R., KOÇAK Z.

Turk Onkoloji Dergisi, cilt.24, sa.2, ss.65-72, 2009 (Scopus, TRDizin) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 2
  • Basım Tarihi: 2009
  • Dergi Adı: Turk Onkoloji Dergisi
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.65-72
  • Anahtar Kelimeler: LDH level, Nasopharyngeal carcinoma, Performance status, Radiotherapy
  • Trakya Üniversitesi Adresli: Evet

Özet

OBJECTIVES: To evaluate the prognostic factors in patients treated with radiotherapy for locally advanced nasopharyngeal carcinoma. METHODS: Forty-eight patients (37 males, 11 females) treated between September 1999 and September 2007 were assessed retrospectively. RESULTS: Ten patients (21%) recurred loco-regionally. Gender (p=0.022), Eastern Cooperative Oncology Group (ECOG) performance status (PS) (p<0.0001), hemoglobin (Hb) (p=0.0035), and lactate dehydrogenase (LDH) (p=0.032) were prognostic for loco-regional control. On multivariate analysis, only PS (p<0.003) remained significant. Eighteen (38%) patients had distant metastases. On univariate analysis, PS (p=0.022), Hb (p=0.002), alkaline phosphatase (ALP) (p=0.004), LDH (p=0.007), and completion of radiotherapy (p=0.014) were prognostic for distant metastasis. On Cox regression analysis, only LDH (p=0.001) remained significant. There were 27 deaths at the time of analysis. On logrank analysis, PS (p=0.012), completion of radiotherapy (p<0.0001), metastasis (p=0.018), and LDH (p=0.018) were prognostic for overall survival. On Cox regression analysis, only LDH (p=0.026) remained significant. CONCLUSION: The pre-treatment LDH was prognostic for distant metastasis and overall survival while PS was prognostic for loco-regional control.