Positive mixed lymphocyte culture test result due to hla-dp mismatch HLA-DP uyumsuzluǧuna baǧlı mikst lenfosit kültür testindeki pozitiflik

Ayna T. K., TOZKIR H., ŞENTÜRK ÇİFTÇİ H., GÜRKAN H., Tekgündüz E., ALGÜNEŞ Ç., ...More

Balkan Medical Journal, vol.28, no.2, pp.224-226, 2011 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.5174/tutfd.2009.02852.1
  • Journal Name: Balkan Medical Journal
  • Journal Indexes: Scopus
  • Page Numbers: pp.224-226
  • Keywords: HLA-DP, Mixed lymphocyte culture, Stem cell transplantation
  • Trakya University Affiliated: Yes

Abstract

Graft Versus Host Disease (GVHD) remains a major cause of morbidity and mortality in allogeneic stem cell transplantation (SCT). The MLC assay has been generally accepted as a standard test for determining HLA-D region compatibility. In this study, the MLC test has been carried out on the related recipient-donor couple who were prepared for allogeneic SCT and were found to be matched for HLA-A, -B, -Cw, DR, DQ but not for -DP. The result of the MLC test was positive. We observed that HLA-DP mismatch was responsible for the increased proliferation values in MLC test. © Trakya University Faculty of Medicine.