The Role of H1- and H2-Receptors in the Effect of Compound 48/80 in the Asphyxiation and Body Temperature of Mice
Yonsei Medical Journal, cilt.37, sa.2, ss.97-103, 1996 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 37 Sayı: 2
- Basım Tarihi: 1996
- Doi Numarası: 10.3349/ymj.1996.37.2.97
- Dergi Adı: Yonsei Medical Journal
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.97-103
- Anahtar Kelimeler: Body temperature, Compound 48/80, Histamine, Histamine receptors, Hypoxia
- Trakya Üniversitesi Adresli: Evet
Özet
Contribution of histamine H1- and H2-receptors to the effect of compound 48/80, a potent histamine releaser, upon asphyxiation and body temperature in mice was investigated in the present experiments. Compound 48/80 showed an apparent protective potency against hypoxia and significantly prolonged the latencies for convulsions and death in a dose-dependent manner. Compound 48/80 also decreased the body temperature, which was in relation with the antihypoxic effect. Both the H1-receptor antagonist, dimethindene, and the H2-receptor antagonist, ranitidine, attenuated the hypothermic effect of compound 48/80, indicating the involvement of central histamine through both the H1- and H2-receptors. Ranitidine had no effect on the protective effect of compound 48/80 against hypoxia-induced lethality, whereas dimethindene completely antagonized it. These results suggest that the protective effect of compound 48/80 against hypoxia is mediated through histamine H1-receptors and is not related to its ability to induce hypothermia.