Melatonin regulates oxidative stress and apoptosis in fetal hearts of pinealectomised RUPP rats

DOĞANLAR O., DOĞANLAR Z. B., OVALI M. A., GÜÇLÜ O., Demir U., Doğan A., ...Daha Fazla

Hypertension in Pregnancy, cilt.39, sa.4, ss.429-443, 2020 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1080/10641955.2020.1802595
  • Dergi Adı: Hypertension in Pregnancy
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.429-443
  • Anahtar Kelimeler: apoptosis, fetus, heart, melatonin, oxidative stress, Preeclampsia
  • Trakya Üniversitesi Adresli: Evet

Özet

Objective: This study aimed to investigate the effects of melatonin on cardiac oxidative stress and apoptosis in the fetal heart in RUPP rats. Methods: The fetal heart samples were obtained from melatonin administrated RUPP rats Results: Our results indicate that preeclampsia exacerbated by melatonin deficiency triggers hypoxic conditions, both mis/un-folded protein response, oxidative stress-induced DNA damage and apoptosis. Melatonin treatment provided significant therapeutic effects on fetal hearts via regulating all these stress response at cellular and molecular levels. Conclusion: Melatonin may be considered as a potential molecule for development of preventive strategies to reduce the PE induced risk of cardiovascular diseases in offspring.