Melatonin regulates oxidative stress and apoptosis in fetal hearts of pinealectomised RUPP rats
Hypertension in Pregnancy, cilt.39, sa.4, ss.429-443, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 39 Sayı: 4
- Basım Tarihi: 2020
- Doi Numarası: 10.1080/10641955.2020.1802595
- Dergi Adı: Hypertension in Pregnancy
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.429-443
- Anahtar Kelimeler: apoptosis, fetus, heart, melatonin, oxidative stress, Preeclampsia
- Trakya Üniversitesi Adresli: Evet
Özet
Objective: This study aimed to investigate the effects of melatonin on cardiac oxidative stress and apoptosis in the fetal heart in RUPP rats. Methods: The fetal heart samples were obtained from melatonin administrated RUPP rats Results: Our results indicate that preeclampsia exacerbated by melatonin deficiency triggers hypoxic conditions, both mis/un-folded protein response, oxidative stress-induced DNA damage and apoptosis. Melatonin treatment provided significant therapeutic effects on fetal hearts via regulating all these stress response at cellular and molecular levels. Conclusion: Melatonin may be considered as a potential molecule for development of preventive strategies to reduce the PE induced risk of cardiovascular diseases in offspring.