Akademik Veri Yönetim Sistemi
Nuclear Medicine and Biology, cilt.32, sa.2, ss.165-170, 2005 (SCI-Expanded, Scopus)
The aim of this study is to investigate the potential effect of increased arterial saturation of oxygen in the magnitude of technetium-99m-hexakis- isobutyl-isonitrile (99mTc-MIBI) uptake in tumor tissue and to compare the results with those of conventional 99mTc-MIBI tumor imaging in the same patient with lung cancer. A total of 26 lung cancer patients underwent initial SPECT (I-SPECT) and after oxygen inhalation SPECT (O 2-SPECT). The early (ER) and delayed ratios (DR) of O 2-SPECT mean±S.D. were significantly higher than those of I-SPECT mean±S.D. (2.07±0.57 vs. 1.90±0.48 and 2.02±0.45 vs. 1.83±0.39, respectively). There are increased rates for the relative tumor uptake of 99mTc-MIBI by 9% for ER and 10% for DR on the O2-SPECT compared to I-SPECT. We found that 99mTc-MIBI uptake increased significantly in the tumor tissue with O2-SPECT compared to I-SPECT. In conclusion, 99mTc-MIBI scintigraphy is one of the main methods for differentiating viable and nonviable tissue fractions in tumors. We consider that 99mTc-MIBI uptake increase after oxygen inhalation is an indicator of positive acute cellular response of the tumor tissue to the rising tissue oxygen level. © 2005 Elsevier Inc. All rights reserved.