Development and evaluation of novel chromone-functionalized benzo crown ether-based poly (vinyl chloride) nanofibers by electrospinning
EUROPEAN POLYMER JOURNAL, cilt.225, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 225
- Basım Tarihi: 2025
- Doi Numarası: 10.1016/j.eurpolymj.2025.113719
- Dergi Adı: EUROPEAN POLYMER JOURNAL
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, Compendex, INSPEC
- Anahtar Kelimeler: Antibacterial, Chromone, Crown ether, Electrospinning, Poly (vinyl chloride), Radical scavenging
- Trakya Üniversitesi Adresli: Evet
Özet
Macrocycles play an extremely tremendous and indispensable role in medicine, engineering, as well as chemistry. The use of electrospun fibers for a wide variety of these fields can be extremely advantageous as they allow the fabrication of highly efficient materials functionalized with active compounds. During our research efforts, a series of nanofibers based on a chromone-functionalized benzo crown ether (CFB15C5)-loaded poly (vinyl chloride) (PVC) with antioxidant and antibacterial activities are designed by facile electrospinning method (PVCCFB15C5-1, 3 and 6). The CFB15C5 was synthesized by the condensation reaction between 4 '-aminobenzo-15- crown-5 (4AB15C5) and 3-formyl-6-methylchromone in propyl alcohol media. The characteristic behaviors of the electrospun fibers were evaluated by analyzing the effects of CFB15C5 loading ratio within the PVC (1, 3 and 6 %, w/w). The resulting fibers exhibited a uniform, nano-scaled, and bead-free morphology with cylindrical shape. The PVC-based samples with higher CFB15C5 loading (6 %, w/w) allowed to attain thicker diameter and more hydrophilic structure compared to electrospun nanofibers containing 1 or 3 % of CFB15C5 (w/w). All of the nanofibers exhibited good antioxidant and antibacterial activity. Based on the DPPH center dot and ABTS center dot+ assays, it was observed that PVC-CFB15C5-6 had higher free-radical-scavenging activity than that of neat the PVC and the other counterparts. Moreover, the fabricated nano-scale electrospun fibers inhibited strains of Gram-negative Pseudomonas aeruginosa ( P. aeruginosa) except Escherichia coli ( E. coli), and Gram-positive Staphylococcus aureus (S. aureus), Enterococcus faecalis (E. faecalis) pathogenic bacteria, and the higher CFB15C5-loaded electrospun nanofibers demonstrated the best inhibition potential against to the both types of bacteria. Overall, the research reported here may offers a new perspective to better understand the systematic potential of crown ether-based polymeric fibers, especially in the healthcare and food industries.