Comparison of survival between unilateral and bilateral breast cancers using propensity score matching: a retrospective single-center analysis

ÖZLER T., COŞAR R., SÜT N., NURLU D., PARLAR Ş., ATEŞ S., ...Daha Fazla

Breast Cancer Research and Treatment, cilt.210, sa.3, ss.673-686, 2025 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 210 Sayı: 3
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1007/s10549-024-07606-1
  • Dergi Adı: Breast Cancer Research and Treatment
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, Gender Studies Database, Veterinary Science Database
  • Sayfa Sayıları: ss.673-686
  • Anahtar Kelimeler: Bilateral breast cancer, Breast Cancer, Metachronous bilateral breast cancer, Multivariate cox regression analysis with backward stepwise, Propensity score analysis, Synchronous bilateral breast cancer, Unilateral breast cancer
  • Trakya Üniversitesi Adresli: Evet

Özet

Purpose: The characteristics of patients with bilateral and unilateral breast cancer at the time of diagnosis or during follow-up have been compared, focusing on the differences in disease-free survival and overall survival between these groups. Methods: A total of 1,947 patients diagnosed with invasive carcinoma were included in the study. 1876 ​​(96.4%) of our patients had unilateral and 71 (3.6%) had bilateral breast cancer. Among the bilateral breast cancer patients n = 47 were metachronous, while n = 24 were synchronous. Results: SBBC, which had the lowest OS duration, showed a statistically significant difference compared to MBCC, similar to that observed in unilateral breast cancer (p = 0.027). Conclusion: The fact that SBBC has the lowest survival rate despite more aggressive treatments should be considered a poor prognostic factor for survival on its own.