Akademik Veri Yönetim Sistemi
Journal of Applied Polymer Science, cilt.120, sa.1, ss.441-450, 2011 (SCI-Expanded, Scopus)
For to be used in controlled releasing of piperacillin-tazobactam, a series of semi and full IPN type hydrogels composed of acrylic acid (AA), acrylamide (AAm) and Chitosan (CS) were prepared via free-radical polymerization. Ethylene glycol dimethacrylate (EGDMA) was used for crosslinking of PAAm and PAA chains to form semi-IPN hydrogels. However, the full-IPN type hydrogels were prepared by using glutaraldehyde (GA) and EGDMA as cocrosslinkers. Characteristics of the hydrogels were investigated by swelling experiments and SEM and FTIR analysis. Generally, full-IPN type hydrogels swell much more than the semi-IPN types. By comparing the full-IPN type hydrogels in between, it is found that the increasing amount of GA causes the decreasing in S% values from 4860 to 4300%. Releasing of piperacillin-tazobactam from selected three hydrogels were investigated in phosphate buffer solution at pH = 7.4, 37°C. The kinetic release parameters, n and k were calculated and non-Fickian type diffusion was established for these hydrogels. The behaviors of the piperacillin-tazobactam loaded hydrogels in Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) culture suspensions were also studied and the statistically significant differences for the microorganism growth values were determined. © 2010 Wiley Periodicals, Inc.