Plasma Total Homocysteine Levels and Other Cardiovascular Risk Factors in Esseentially Hypertensive Patients With Microalbuminuria
TURKISH NEPHROLOGY DIALYSIS AND TRANSPLANTATION JOURNAL, cilt.16, sa.3, ss.122-128, 2007 (ESCI)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 16 Sayı: 3
- Basım Tarihi: 2007
- Dergi Adı: TURKISH NEPHROLOGY DIALYSIS AND TRANSPLANTATION JOURNAL
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
- Sayfa Sayıları: ss.122-128
- Trakya Üniversitesi Adresli: Hayır
Özet
The aim of the present study ores to investigate the pasma total homocysteine levels end other risk factors for cardrovascular disease in microalbuminurie essentially hypertensive patients and to compare with those of non-rnicroalbuminoric ones. Plasma total homocrysteine, levels were determined ill essentially hypertensive patients (n-45) and compared with those of the controls (n=14). Then, the patient group was tivided into two subgroups as microalbuminuric and non-micrnal buminuric. Both subgroups were also compared to each other re:with respect to determined parameters including plasma total homocysteine levels. Plasma total homocystetaine levels of the patients (12.51 +/- 6.58 mu mol/L).(11 were lower: but not significantly (p=0.795), than those of the controls (13.28 +/- 11.11 mu mol/L). Microarburninuric (12.82 +/- 6.01 mu mol/L) and non-miurralhuminuric (12.06 +/- 7.45 mu mol/L) patients did not show a statistically significant difference from each other with respect to plasma total homocysteine levels. Similarly, plasma total homocystine levels were also not different between the. patients wall and without hypertensive retinopathy in the main (p=0.648), microalburrrinuric (p=0.721) and non-microoalbuminuric 1)(p=.0.246) patient groups. However, serum LDL cholesterol lev. of microalbuminuric patients (111.76 +/- 30.10 mg/dL) were significantly higher than those of the non-microalhormnuric patients (87.43 +/- 30.39 mg/dL) (p=0.037). It suggests that plasma total homocysteine levels do not involve in the pathogenesis of microalbuminuria and retinopathy in patients with essential hypertesion, but microalbuminuria in these patients seems to he affected by serum LDL cholesterol levels,