Importance of p53, bcl-2, p21WAF1 and PCNA positivities in renal angiomyolipomas
Biomedical Research (India), cilt.28, sa.10, ss.4696-4702, 2017 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 10
- Basım Tarihi: 2017
- Dergi Adı: Biomedical Research (India)
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.4696-4702
- Anahtar Kelimeler: Angiomyolipomas, P53, Renal
- Trakya Üniversitesi Adresli: Evet
Özet
Angiomyolipomas are tumors of the kidneys which are often benign in character with a potential for malignant transformation. The benign-malign distinction in these tumors can be made only with clinical follow-up as they exhibit the same microscopic appearance. In the present study, immunohistochemical investigation has been performed for p53, p21WAF1, PCNA and bcl-2, which may be markers for the histological distinction of benign and malignant cases. The p53, p21WAF1, PCNA and bcl-2 investigations in 10 tumor tissues with AML revealed significantly higher p53 positivity in 3 patients. The clinical follow-up of these three patients showed malignant progression. In conclusion, we believe that p53 positivity may be an appropriate marker for the benign-malign distinction in AML tumors.