7′,8′-Dihydroobolactone, a typanocidal α-pyrone from the rainforest tree Cryptocarya obovata

Davis R. A., DEMİRKIRAN Ö., Sykes M. L., Avery V. M., Suraweera L., Fechner G. A., ...Daha Fazla

Bioorganic and Medicinal Chemistry Letters, cilt.20, sa.14, ss.4057-4059, 2010 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 14
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.bmcl.2010.05.091
  • Dergi Adı: Bioorganic and Medicinal Chemistry Letters
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.4057-4059
  • Anahtar Kelimeler: 7′,8′-Dihydroobolactone, A549, Antitrypanosomal, Cryptocarya obovata, HEK293, HeLa, MCF-7, Trypanosoma brucei brucei
  • Trakya Üniversitesi Adresli: Evet

Özet

Mass-directed isolation of the CH2Cl2/MeOH extract from the leaves of Cryptocarya obovata resulted in the purification of a new trypanocidal α-pyrone, 7′,8′-dihydroobolactone (1). The chemical structure of 1 was determined by 1D/2D NMR, MS and CD data analysis. 7′,8′-Dihydroobolactone was shown to inhibit Trypanosoma brucei brucei with an IC50 of 2.8 μM. © 2010 Elsevier Ltd. All rights reserved.