Akademik Veri Yönetim Sistemi
Italian Journal of Pediatrics, cilt.33, sa.5, ss.268-272, 2007 (Scopus)
Aim. Chronic diseases are thought to inhibit growth by influencing growth hormone-insulin like growth factor 1 axis. Since Familial Mediterranean Fever is also a chronic disease, this study aimed to assess the progression of growth in children with Familial Mediterranean Fever in detail. Methods. Overall 42 patients with Familial Mediterranean Fever and 42 healthy children were included in this prospective study. Insulin like growth factor 1 levels were studied in all cases. Bone age was determined by X-ray of left hand and wrist. Puberty was evaluated by physical examination via Tanner Staging. Height was measured at 6-month intervals and growth velocity was calculated. Results were compared with the control group and the correlation between variables was investigated. Results. Of the 42 Familial Mediterranean Fever patients (25 females, 17 males) on colchicine treatment, 26 were in prepubertal and 16 were in pubertal period. Mean age was 10.87 ± 3.36 years. The healthy control group consisted of 42 children (19 males, 23 females) of whom 25 were in prepubertal and 17 in pubertal period. Mean age of the control group was 10.36 ± 4.04 years. Growth velocity and insulin like growth factor 1 levels of children with Familial Mediterranean Fever, whose diseases were controlled by colchicine, were not different from age-matched controls. Total colchicine dose showed a positive correlation with height and insulin like growth factor 1 levels, this supporting the idea that colchicine while inhibiting disease activity, does not have a negative effect on growth. Conclusion. Growth of children with Familial Mediterranean Fever, in remission by colchicine treatment, was not different from healthy children of the same age.